|
|
| Year : 1998 | Volume
: 41
| Issue : 4 | Page : 443-52 |
|
|
External clues to inner malformations.
D Gupta, K Vaiphei, C K Banerjee, K Joshi, R K Vashishta, B D Radotra, A Das, A K Banerjee
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Correspondence Address:
D Gupta
Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 9866906 
|
|
|
A malformation is a morphological defect of an organ, or a larger region of the body resulting from an intrinsically abnormal developmental process. In this analysis of 1421 neonatal autopsies performed between 1984 and 1993, 243 (17.1%) cases showed malformations. The data was analysed to find external cues to internal malformations. Twenty three (85%) of the 27 neonates with various facial abnormalities had associated internal malformations in the form of cardiac (n = 11; 40%), renal (n = 7; 25%), or gastrointestinal (n = 3; 11%) abnormalities and diaphragmatic hernia (n = 2). Sixty seven neonates had neural abnormalities. These were associated with cardiac (n = 7; 10%), renal (n = 12; 18%) or gastrointestinal (n = 7; 10%) abnormalities; 43 cases, however, did not have any associated malformations. Renal malformations (n = 66) had highest association with skeletal abnormalities (n = 9; 22%). As many as 45(76%) of the 59 cases with cardiac abnormalities had no external anomalies. Five cases of hypoplastic lungs were seen, all associated with external malformations. |
|
|
|
| [PDF]* |
|
 |
|
