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| Year : 1998 | Volume
: 41
| Issue : 4 | Page : 423-6 |
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A simple screening test for the detection of heterozygous beta thalassemia.
A A Thool, M S Walde, A V Shrikhande, V H Talib
Department of Laboratory Medicine, Safdarjung Hospital, New Delhi
Correspondence Address:
A A Thool
Department of Laboratory Medicine, Safdarjung Hospital, New Delhi
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 9866902 
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Beta-Thalassemia is prevalent in a high frequency of 5-15% in selected geographical areas and ethnic communities. There is need to screen large populations for the heterozygotes of beta-Thalassemia. We have evaluated NESTROFT (Naked eye single tube red cell osmotic fragility test) with 0.36% buffered saline in this study. Of the population screened, 42 cases were positive with NESTROFT, of which 40 were positive with the confirmatory test for beta-Thalassemia. This implies a positive predictive value and specificity of 100%, negative predictive value of 83.3% and sensitivity of 95.2%. |
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