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| Year : 1998 | Volume
: 41
| Issue : 4 | Page : 387-90 |
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Seroepidemiology of ocular toxoplasmosis-profile of an urban population.
S D Jain, B Uppal, D K Mehta
Department of Microbiology, Safdarjang Hospital
Correspondence Address:
S D Jain
Department of Microbiology, Safdarjang Hospital
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 9866896 
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200 uveitis cases and 100 controls were serologically analysed for Toxoplasma antibodies (Ab) using indirect fluorescent antibody test (IFAT-IgG, Igm) and enzyme linked immunosorbent assay (ELISA IgG, IgM). Ophthalmologically cases were segregated into 4 groups anterior uveitis, posterior uveitis, pan uveitis and varied presentation uveitis. Toxoplasma seropositivity of 32% in cases and 4% in controls was established. IHA, IFAT, ELISA detected 20%, 18% and 32% cases as seropositive respectively, IFAT being most specific (100%) and ELISA most sensitive (41.37%). Insignificant change in Ab titre was observed in sequential samples of seropositive cases. Posterior Uveitis cases had the maximum seropositivity (41.7%). Highest seropositivity was in 16-25 years age group with no sex preponderance. Dietary habits and occupational history had no bearing on Toxoplasma infection. Results indicate that serology in mandatory for diagnosing Toxoplasma as a cause of uveitis, 2 or more tests on a single serum sample detecting IgG and Igm Ab are the best indicators of infection. |
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