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| Year : 1998 | Volume
: 41
| Issue : 3 | Page : 331-5 |
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Langerhans cell histocytosis--a clinicopathological spectrum.
N Jayaram, A V Ramprasad, R P Sujay
Anand Institute of Laboratory Medicine, Bangalore
Correspondence Address:
N Jayaram
Anand Institute of Laboratory Medicine, Bangalore
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 9805856 
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Langerhans cell Histiocytosis--a lesion characterised by proliferation of a variant of epidermal dendritic cell is one of the several syndromes in which histiocytes play a principal role in pathogenesis outside the context of inflammatory and metabolic storage disease. Seven cases were diagnosed as Langerhans cell Histiocytosis over a period of six years. The mode of diagnosis was Fine needle aspiration in 2 cases, open biopsy in four, and both biopsy and FNAC in one. The age range was from 2 months to 58 years and four of the seven patients were males. The lesion was unifocal in 3 cases (two in bone and one involving skin and soft tissue), multifocal in 3 and systemic in one. Electron microscopy was done in one case to demonstrate Birbeck granules. Immunohistochemical demonstration of S 100 protein was done in one case. The clinicopathologic spectrum of Langerhans cell Histiocytosis is brought out in this presentation of seven cases. |
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