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| Year : 1996 | Volume
: 39
| Issue : 3 | Page : 179-85 |
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Renal amyloidosis--a clinicopathologic study.
V B Shah, A M Phatak, B S Shah, B M Kandalkar, A R Haldankar, S Ranganathan
B.Y.L. Nair Hospital, Bombay
Correspondence Address:
V B Shah
B.Y.L. Nair Hospital, Bombay
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 8972145 
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A total of 19,075 necropsies and 1169 renal biopsies were scrutinised over a period of 20 years (1973-1992) retrospectively with an aim to study the incidence and pattern of renal amyloidosis in Nair Hospital. A total of 75 cases with amyloidosis were detected, 33 from the necropsy series (0.162%) and 42 from biopsies (3.59%). Secondary amyloidosis was seen in 82.66% and primary amyloidosis in 10.66%. Tuberculosis of various organs was the main cause of secondary amyloidosis (79.03%). Nephrotic syndrome was the common mode of presentation (52%). Besides kidney, which were involved in all cases, the liver, spleen and adrenals were other commonly involved organs at necropsy. Renal failure was the leading cause of death (51.51%). Thioflavine-T proved to be more sensitive technique than other conventional staining methods. The potassium permanganate test is a useful test to distinguish secondary amyloid fibrils from other amyloid fibrils. Abdominal fat aspiration may prove to be specific, sensitive and a routine procedure enabling the early diagnosis of amyloidosis leading to increased incidence of amyloidosis during life than at necropsy. |
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