Indian Journal of Pathology and Microbiology
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Year : 1995  |  Volume : 38  |  Issue : 4  |  Page : 383-8

Role of AgNORs in diagnosis of early malignant lesions of gall bladder.

Department of Pathology and Gastoenterology, M.L.N. Medical College, Allahabad

Correspondence Address:
V Misra
Department of Pathology and Gastoenterology, M.L.N. Medical College, Allahabad

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Source of Support: None, Conflict of Interest: None

PMID: 9726148

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Sections from eighty nine specimens of gall bladder including 40 cases of chronic cholecystitis, 9 dysplasia 15 well differentiated adenocarcinoma, 14 moderately differentiated adenocarcinoma and 11 poorly differentiated adenocarcinomas were studied for argyrophilic nucleolar organizer regions (AgNOR's). The difference between mean +/- SD NOR counts of chronic cholecystitis (1.97 +/- 0.28), dysplasia (5.6 +/- 0.88) well differentiated adenocarcinoma (7.2 +/- 0.30) and moderately differentiated adenocarcinoma (8.0 +/- 0.63) was statistically significant (p < 0.001). NOR counts of poorly differentiated adenocarcinoma (8.5 +/- 0.78) were higher than moderately differentiated carcinoma but the difference was not statistically significant. Despite the significant difference in the mean values, a considerable overlap in the NOR counts of individual cases of different groups was observed suggesting that though NOR counts can not act as a specific diagnostic parameter for diagnosis of early carcinoma and dysplasia in isolated cases, they may prove to be a good adjunct to already existing parameters like imaging techniques or cytology.

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