Indian Journal of Pathology and Microbiology
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Year : 1995  |  Volume : 38  |  Issue : 3  |  Page : 267-71

Bone marrow involvement in Hodgkin's disease -- clinicopathological study of seven cases.

Departments of Pathology and Medicine, Christian Medical College, Ludhiana

Correspondence Address:
R Chopra
Departments of Pathology and Medicine, Christian Medical College, Ludhiana

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Source of Support: None, Conflict of Interest: None

PMID: 8819658

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Bone marrow involvement was observed in 7 cases amongst a total of 75 cases of Hodgkin's disease encountered between January 1981 and June 1990; thus representing an incidence of 9.3 percent. Analysis of these 7 cases showed male preponderance. The age ranged from 26 to 74 years. All patients presented within seven months of onset of symptoms; and all had symptoms at presentation. Lymphadenopathy was found in all the cases, splenomegaly was present in six; and hepatomegaly in 4 cases. Mixed cellularity and lymphocytic depletion subtypes showed the highest frequency of marrow involvement (6 cases; 85.7 percent). Alkaline phosphatase was raised in 6 cases (85.7%). All cases received standard combination chemotherapy with or without local radiation therapy. Two years follow-up revealed an overall survival of 42.9%. Replace free survival at the end of two years was zero, as all the cases relapsed within seven months of initiation of treatment.

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